Last updated: 2023-09-28

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Knit directory: cirrhosis-metabolism/

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About

In this project the expression of genes involved in the metabolism of xenobiotic substances is analyzed in a mouse model that develops chronic liver disease induced by administration of CCl4 for 2, 6 and 12 months (Holland et al. 2021). In addition their expression in mouse is compared against the expression in patients that suffer from chronic liver disease utilizing a set of publicly available patient cohorts (see Table 1 in Holland et al. (2021) for more details)

The focus is on the following gene families:

References

Holland, Christian H., Ricardo O. Ramirez Flores, Maiju Myllys, Reham Hassan, Karolina Edlund, Ute Hofmann, Rosemarie Marchan, et al. 2021. “Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice.” Hepatology Communications 6 (1): 161–77. https://doi.org/10.1002/hep4.1797.